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Under ideal assay conditions the
2020-08-03
Under ideal assay conditions the Km and Vmax for different substrates were determined for all the enzyme forms. In both cases, immobilization onto Glut-P and IAM, the Km and Vmax showed a decrease. This is understandable when one considers the effects of diffusion. The diffusion of the substrate fro
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Under ideal assay conditions the
2020-08-03
Under ideal assay conditions the Km and Vmax for different substrates were determined for all the enzyme forms. In both cases, immobilization onto Glut-P and IAM, the Km and Vmax showed a decrease. This is understandable when one considers the effects of diffusion. The diffusion of the substrate fro
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br Genes encoding the DGAT enzymes br
2020-08-03
Genes encoding the DGAT enzymes Membrane topology and structure-function relationships The evolutionary divergence in the gene sequences of the DGAT enzymes is reflected in their predicted protein structures [73]. Through multiple sequence alignment of DGATs, including 59 DGAT1s from 48 organi
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Talarozole The significance of DDR receptor in
2020-08-03
The significance of DDR2 receptor in the skeleton growth of human being could not be ignored, which has revealed by analysis of rare genetic disease, chondrodysplasia termed as spondylometa-epiphyseal dysplasia (SMED-SL) with short limbs and abnormal calcifications. This Autosomal disease has been c
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Dopamine affects cognition especially in prefrontal cortex d
2020-08-01
Dopamine affects cognition, especially in prefrontal cortex, due to its role in attention, vigilance, sleep and arousal. Increased dopaminergic prefrontal activity/availability is associated with improved working memory, attention and other executive functions [7]. Catechol-O-methyltransferase (COMT
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Persimmon Diospyros kaki L fruit is reported to exert
2020-08-01
Persimmon (Diospyros kaki L.) fruit is reported to exert hypocholesterolaemic properties in some animal models. It has been found that dietary persimmon fruits prevented hypercholesterolaemia in rats fed with cholesterol diets (Gorinstein, Bartnikowska, Kulasek, Zemser, & Trakhtenberg, 1998). Matsum
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br Patients and methods br Results
2020-07-31
Patients and methods Results The study (-)-Bicuculline methobromide consisted of 96 children and adolescents. Thirty-nine subjects were girls and 57 were boys (Table 1). The mean age of the study population was 6.6 ± 0.5 (SE) years ranging from 0.10 to 15.94 years, and there was no difference
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br Introduction Esophageal squamous cell carcinoma ESCC is
2020-07-31
Introduction Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer in East Asia and is a leading cause of cancer-related death worldwide.1, 2 Surgery is widely used for treatment in localized disease, where it can provide definitive management and potential cure. Tre
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Classically the D R family
2020-07-31
Classically, the D1R family activates the Gαs/olf family of G proteins, leading to activation of adenylyl cyclase (AC) and increased cAMP production, whereas the D2R class recruits Gαi/o signaling to inhibit AC and cAMP production (Beaulieu and Gainetdinov, 2011). In striatal spiny projection neuro
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Another important issue that requires clarification is the c
2020-07-31
Another important issue that requires clarification is the contribution of TLS regulators to replication of undamaged DNA. TLS pols are certainly required for the synthesis across difficult-to-replicate DNA structures such as common fragile sites [4], but their participation in undamaged DNA replica
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MPC 6827 hydrochloride DG and PA consist of various
2020-07-31
DG and PA consist of various molecular species with different acyl chains at the sn-1 and sn-2 positions, and consequently, mammalian MPC 6827 hydrochloride contain more than 50 structurally distinct DG/PA species. DGK is a component of PI turnover and initiates PI regeneration (Hodgkin et al., 1998
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br Methods of calculations The results of this
2020-07-31
Methods of calculations The results of this work have been compared with those recently reported in the Ref. [5]; therefore all calculations and molecular simulations have been performed using the same techniques previously used. Experimental section Results and discussion We recently repo
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br Discussion When NAT was
2020-07-31
Discussion When NAT1 was deleted from MDA-MB-231 and HT-29 cells, there was a marked decrease in oxidative phosphorylation, which was associated with a decrease in PDH-E1α activity. Inhibition of the pyruvate dehydrogenase complex limits pyruvate entry into the TCA cycle and lowers ATP generation
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We did not find any significant associations between APOE
2020-07-31
We did not find any significant associations between APOE genotype and BDI-II, BAI, or PAI clinical scale scores. Our results indicate that APOE is not likely to play a major role in psychiatric comorbidities in epilepsy. This is in line with studies in the general population, which have not found a
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Further characterization of other plasmin plasminogen bindin
2020-07-30
Further characterization of other plasmin/plasminogen binding proteins of Mtb can delineate the significance of pathophysiology of TB in relation with its tissue invasive potential. Chemical therapeutics against the lysine dependent binding of plasminogen to these surface localized moonlighting prot
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