• br Acknowledgments We apologize to the researchers who were

  2022-03-04

  

  Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. This work was supported by grants from the US National Institu

• Remarkably most of these molecules are also quite effective

  2022-03-04

  

  Remarkably, most of these molecules are also quite effective in interfering with the proliferation of the drug-resistant cancer cell lines, with IC50 values ranging from 0.59 to 2.93 μM against MCF-7/ADR cells, and from 0.160 to 1.17 μM against NSCLC-resistant H1975 cells. Among these molecules, co

• br METHODS br RESULTS br Discussion

  2022-03-03

  

  METHODS RESULTS Discussion Numerous studies have proposed various hypotheses and models to explain how neuroinflammation could contribute to the chronic fatigue, postexertional fatigue, and cognitive deficits observed in patients with ME/CFS.12, 13, 14, 15 Although neuroimaging studies have

• Based on these findings we

  2022-03-03

  

  Based on these findings, we set out to identify GPR109A agonists capable of biasing the receptor's signaling towards the functional anti-lipolytic and presumed therapeutic response, and away from the flushing side-effect pathways. Indeed, using recombinantly expressed GPR109A, two classes of compoun

• New follicular wave emergence is associated closely with the

  2022-03-03

  

  New follicular wave emergence is associated closely with the stage of the estrous EPZ015666 (Sirois and Fortune, 1988). As indicated by results from the present experiment, cows that had regression of the largest follicle on Day 0 of treatment onset had follicle wave characteristics that were consi

• In three groups independently proposed two

  2022-03-03

  

  In 2001, three groups independently proposed two different mechanisms for the catalytic reaction of GlxI [5], [6], [7]. Richter and Krauss (RK) used HF/4–31G calculations of the active site, coupled with a frozen effective fragment potential description [8], [9] of eleven residues in the binding sit

• Functional studies based on patch

  2022-03-03

  

  Functional studies based on patch-clamp electrophysiology provide additional information on the active state of GlyR α1. Current-voltage measurements from single BCECF-AM in outside-out patches at symmetric 145-mM chloride concentration yielded a unitary conductance of 86 pS for the main open state

• Cortisol is a natural glucocorticoid hormone

  2022-03-03

  

  Cortisol is a natural glucocorticoid hormone produced by the adrenal cortex. Its secretion is stimulated by the sympathetic nervous system, and its main function is to mobilize energy to protect the homeostasis of vital biochemical processes during physical and psychological stress [14]. Chronic lev

• br Materials and methods br Results

  2022-03-03

  

  Materials and methods Results Discussion Acknowledgments Introduction As we move into an aging society, there has been a growing interest in neurological disorders [1]. Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) cause cognitive malfunction

• br Genetic rescue of GluR

  2022-03-03

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific Prote of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005). This g

• The Hedgehog Hh pathway is linked to the

  2022-03-02

  

  The Hedgehog (Hh) pathway is linked to the development of several types of epithelial cancers (Rubin and de Sauvage, 2006). A paracrine mechanism has been implicated in CAF activation, with Hh ligands secreted by cancer cells activating the glioma-associated transcription factors (Gli) in surroundin

• br FXR FGF in the control

  2022-03-02

  

  FXR–FGF15/19 in the control of BAs synthesis The nuclear receptor FXR is the master regulator of BAs homeostasis, modulating their synthesis, Ketorolac tromethamine salt and uptake [15]. FXR decreases BA de novo hepatic biosynthesis by reducing the expression of CYP7A1. At the canalicular membr

• Analysis of published albumin X

  2022-03-02

  

  Analysis of published albumin X-ray structures had suggested that an allosteric link may exist, but could not establish whether Zn2+ prevented FFA binding or vice versa. This question was answered through competition experiments monitored by isothermal titration calorimetry (ITC; Fig. 3) for BSA [55

• Growing evidence supporting the anti

  2022-03-02

  

  Growing evidence supporting the anti-inflammatory and tissue-protective effects of FPR antagonists led to the screening of commercial libraries for novel small-molecule FPR antagonists. As result of these screening efforts and/or structure–activity relationship (SAR)-directed design and synthesis, a

• br Molecular mechanisms and pathways for

  2022-03-02

  

  Molecular mechanisms and pathways for ferroptosis regulation As to the regulation of lipid peroxidation, iron and related ROS metabolism involved in ferroptosis, many molecular mechanisms and pathways have been presented. It is generally believed that cystine/glutamate antiporter system Xc−, GPX4

15408 records 459/1028 page Previous Next First page 上5页 456457458459460 下5页 Last page