• 2'3'-cGAMP (sodium salt): Mechanistic Insights into Endot...

  2025-09-23

  Explore the mechanistic role of 2'3'-cGAMP (sodium salt) in orchestrating endothelial STING-mediated innate immune responses, with emphasis on its impact for cancer immunotherapy and vascular normalization. This article provides novel perspectives for research leveraging this potent STING agonist.

• Berberine (CAS 2086-83-1): Bridging AMPK Activation and I...

  2025-09-22

  This article explores the multifaceted role of Berberine (CAS 2086-83-1) as an isoquinoline alkaloid, highlighting its unique capacity as an AMPK activator for metabolic regulation and its emerging relevance in inflammation pathways, particularly in the context of inflammasome research. The discussion integrates recent mechanistic insights and provides practical guidance for metabolic disease and i

• Advanced Applications of EZ Cap™ EGFP mRNA (5-moUTP) in m...

  2025-09-19

  Explore the unique capabilities of EZ Cap™ EGFP mRNA (5-moUTP) for enhancing mRNA stability and suppressing innate immune activation in translational research. This article examines the interplay of capped mRNA with Cap 1 structure, 5-moUTP incorporation, and poly(A) tail engineering for robust gene expression and advanced in vivo imaging.

• ABT-737 and the Mitochondrial Apoptosis Pathway: A Tool f...

  2025-09-18

  Explore how ABT-737, a potent BH3 mimetic and BCL-2 protein inhibitor, advances mechanistic studies of apoptosis induction in cancer cells. This article highlights novel intersections with recent findings on mitochondria-mediated cell death signaling.

• AKT has been shown to be

  2025-03-03

  

  AKT1 has been shown to be important for G1-S checkpoint transition and proliferation, whereas AKT2 regulates cell-cycle exit through its interaction with p21 (Héron-Milhavet et al., 2006). In a recent study in triple negative breast cancer, AKT3, rather than AKT1 activity was most important for cell

• Nrf br AhR br Nrf and

  2025-03-03

  

  Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r

• hydroxydopamine OHDA is a selective catecholaminergic neurot

  2025-03-03

  

  6-hydroxydopamine (6-OHDA) is a selective catecholaminergic neurotoxin mainly used to generate lesions in the nigrostriatal pathway in rats (Ungerstedt, 1968). The most common use of 6-OHDA is via unilateral injection into the rat medial forebrain bundle (MFB). DA depletion, nigral DA cell loss, and

• Demethoxycurcumin The central problem in amnesia developing

  2025-03-03

  

  The central problem in amnesia developing following impairment of long-term memory consolidation or reconsolidation is a question of the underlying mechanisms, whether it is caused by impairment of retrieval or memory storage mechanisms [3,8,9,[15], [16], [17], [18]]. To answer this question, severa

• In order to increase the oral

  2025-03-03

  

  In order to increase the oral bioavailability, abiraterone (157) is being used in the form of its 3β-acetoxy prodrug, abiraterone acetate (156). In spite of the fact that high-fat meals increase the oral GW 6471 australia of abiraterone acetate (156), it is recommended that this drug should be take

• Our research is the first

  2025-03-01

  

  Our research is the first to report that administration of HMW-HA is an effective strategy to defend against PM2.5-induced disruption of pulmonary epithelial barrier and lung injury, and addresses that HMW-HA restricts PM2.5-induced epithelial apoptosis through reducing oxidative stress and followin

• br Results br Discussion ER and GR play opposite

  2025-03-01

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• FSLLRY-NH2 br Material and methods br Results br Discussion

  2025-03-01

  

  Material and methods Results Discussion This study explores the hypothesis that ASK1, via transcriptional upregulation by E2F1, molecularly defines AT that supports a dys-metabolic obese phenotype in humans. We demonstrate associations between increased visceral-AT ASK1 expression and multi

• Inflammations lead to the perturbation of aromatase

  2025-03-01

  

  Inflammations lead to the perturbation of aromatase enzyme [112], which normally is responsible for a broad array of critical functions. Chemotherapy targets this enzyme, so this treatment option is never side-effect-free and not fully-effective. Therefore, the mankind should be careful so as not to

• Another major problem leading to implant failures

  2025-03-01

  

  Another major problem leading to implant failures is post-implant infections, majorly due to bacteria adhesion [13,36,37]. A significant decrease in bacterial counts (~65–90%) has been observed in HA and/or CNT-based composites reinforced with 2.5–10 wt% nano Ag [13,38], thus, drawing the conclusion

• The studies have described that Candida non albicans are con

  2025-03-01

  

  The studies have described that Candida non-albicans are considered as remarkable pathogenic agents of OPC, and among them, C. tropicalis and C. glabrata are known as major strains that may replace C. albicans as the greatest causing agent of this infection [20], [21]. It has been shown that Candida

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