• br Ethics br Funding br Conflicts

  2019-04-26

  

  Ethics Funding Conflicts of interest Acknowledgments Case A 68-year-old man with palpitations was referred to our center for catheter ablation because of drug-refractory atrial fibrillation (AF). The preoperative multidetector computed tomography showed a congenital vascular anomaly:

• br Epigenetic regulation of genes involved in hepatic

  2019-04-25

  

  Epigenetic regulation of genes involved in hepatic lipid metabolism by S1P and SHP The signaling cascade of CBA > S1PR2 > SphK2 > S1P > HDAC1/2 > increased hepatic gene expression can differentially up-regulate blocks of genes involved in the hepatic metabolism of sterols and lipids (Fig. 3, Tabl

• Even with the limitations in the

  2019-04-25

  

  Even with the limitations in the available data on DALYs, the funding gap is huge. The Research Investments in Global Health study analysed public and philanthropic infectious disease research awards to UK institutions (1997–2013), and compared them to the burden in DALYs, describing a new metric of

• Abstract Background Substantial progress has

  2019-04-25

  

  Abstract Background Substantial progress has been made in reducing the incidence and prevalence of malaria. In 2016, 111 countries have eliminated malaria and another 35 countries, are making progress toward elimination of the disease. However, little is known about how much governments and donors

• br As one of the few

  2019-04-25

  

  As one of the few countries that have achieved Millennium Development Goals 4 and 5, China has had a remarkable decline in under-5 mortality rate in past three decades. Drivers of such rapid improvement in China have been widely discussed. In , Chunhua He and colleagues report a decline in under-

• Z-IETD-FMK Pilsicainide might increase hERG proteins via fac

  2019-04-25

  

  Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indica

• br The Medical Education Partnership Initiative

  2019-04-25

  

  The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa. MEPI allows African institutions that A-366

• Introduction The assessment of hormonal receptor

  2019-04-24

  

  Introduction The assessment of hormonal receptor (HR) and human epidermal growth factor receptor-2 (HER2) status by immunohistochemistry (IHC) groups breast cancer into three major subtypes: 1) luminal-like subtype (HR positive/HER2 negative); 2) HER2 subtype (HER2 positive and HR negative/positive

• We examined pharmacologic exposures among the subset of wome

  2019-04-24

  

  We examined pharmacologic exposures among the subset of women diagnosed with breast cancer on or after 1995 (N=620) and found that over two thirds (70.8%) received adjuvant endocrine therapy prior to hip or pdgfr inhibitor fracture, including 30.8% who received tamoxifen only, 23.1% who received ar

• It is noteworthy that in

  2019-04-24

  

  It is noteworthy that in a recent study, Le Scouarnec et al. [199]. estimated the burden of rare coding variation in arrhythmia susceptibility genes among 167 BrS index patients and compared that with 167 individuals ≥65 years old with no history of cardiac arrhythmia. The authors concluded that, ex

• br Materials and methods br

  2019-04-24

  

  Materials and methods Results The two groups were similar regarding age, sex, systolic blood pressure, diastolic blood pressure, and heart rate (bpm) (Table 1). LV end-diastolic dimension, LV end-systolic dimension, posterior wall thickness, and LV ejection fraction (%) were not statistically

• La pol tica institucionalizada se convirti y se acept

  2019-04-24

  

  La política institucionalizada se convirtió y se aceptó, por parte de los actores relevantes del sistema (neo-oligarquías e instituciones), y en gran medida por lo benevolente y bondadosa que sería para los intereses del gran capital, como el vehículo hacia el futuro del Estado. Se decretó que la cr

• Introduction Myelodysplastic Syndrome MDS is a

  2019-04-24

  

  Introduction Myelodysplastic Syndrome (MDS) is a heterogeneous clonal disorder characterized by ineffective hematopoeisis and propensity for transformation into Acute Myelogenous Leukemia (AML). The Revised International Prognostic Scoring System (R-IPSS) is an accepted model used to predict overal

• br Discussion The natural history of PMF

  2019-04-23

  

  Discussion The natural history of PMF is characterized by the possibility of blastic transformation in approximately 20% of all the cases [9]. Several factors might predict leukemic transformation, including percentage of circulating blasts, low platelets count and the presence of an unfavorable

• br Conclusions br Disclosures br Funding Sources

  2019-04-23

  

  Conclusions Disclosures Funding Sources Introduction Pulmonary vein isolation (PVI) has become an accepted treatment for atrial fibrillation (AF) [1]. The efficacy of PVI is sometimes insufficient, and atrial substrate modification of target specific AF signals indicating the substrate r

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