• br STAR Methods br Author Contributions br Acknowledgments

  2020-07-27

  

  STAR★Methods Author Contributions Acknowledgments We thank W. Clark and A. Keith for in-house DNA sequencing, J. Gu for technical assistance in phage display, and Diamond Light Source for access to stations I03 and I04 (BAG allocation mx11651). W.Z. is supported by the Mitacs Elevate progra

• br Materials and methods br Results br Discussion

  2020-07-27

  

  Materials and methods Results Discussion A significant decrease in fluorescence was observed after the treatment of pure DNA with alkylating compounds. This decrease was characterized by a dose-response relationship. Mass spectrometry and additional fluorescence measurements ruled out the c

• br Introduction Cysteine proteases are one of

  2020-07-27

  

  Introduction Cysteine proteases are one of the major types of proteolytic enzymes. Their hallmark is the nucleophilic thiol group of the catalytic cysteine residue, which enables the hydrolysis of peptide bonds in various proteins (Brömme, 2001). The most abundant cysteine proteases share a struc

• In the in vitro assays of migration and survival of

  2020-07-27

  

  In the in vitro assays of migration and survival of isolated cancer cells, the low levels of LTD4 produced by the cancer cells alone were obviously sufficient for the observed migratory effects which were sensitive to montelukast. When the cancer cells were treated with pleural exudates-exosomes, Cy

• br Conflicts of interest br Acknowledgements This

  2020-07-27

  

  Conflicts of interest Acknowledgements This work was supported by funding from Young Sanjin Scholars Distinguished Professor, the Aid Program for Innovation Research Team in Shanxi Agricultural University (CXTD201201), and the Special Fund for Agro-scientific Research in the Public Interest of

• br Discussion We and others have shown that a

  2020-07-27

  

  Discussion We and others have shown that a major defect to infectious HIV production in murine cells is due to a block at nuclear export of unspliced and partially spliced viral mRNAs (Coskun et al., 2006; Sherer et al., 2011; Swanson et al., 2010). Not only does this result in reduced viral stru

• br Materials and methods br Results br Discussion Consistent

  2020-07-27

  

  Materials and methods Results Discussion Consistent with previous reports (Barr et al., 2010, Vuong et al., 2010), the current study demonstrates that rats treated with amphetamine exhibit heightened anxiety states during withdrawal. Furthermore, icv. infusion of a CRF2 receptor antagonist

• An inverted U is widely believed to characterize

  2020-07-27

  

  An “inverted-U” is widely believed to characterize the relationship between dopaminergic activity and cognitive performance, in which too much or too little dopaminergic activity has detrimental effects on cognition (Sawaguchi and Goldman-Raikic, 1991). The present findings were consistent with the

• Although many neurotransmitters e g catecholamines serotonin

  2020-07-25

  

  Although many neurotransmitters (e.g., catecholamines, serotonin, and excitatory/inhibitory amino acids) have been implicated in the modulation of anxiety-like responses (Carobrez et al., 2001, Molchanov and Guimaraes, 2002, Vianna et al., 2001), the so-called atypical neurotransmitters, endocannabi

• DNA methylation is a relatively stable but

  2020-07-25

  

  DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla

• The present study failed to

  2020-07-25

  

  The present study failed to demonstrate an independent association of preoperative ChE with BCR. This is in contrast to Koie et al. who reported that pretreatment serum ChE was significantly associated with BCR in 535 patients with CaP who underwent RP (5-year BRFS rates were 77.7% and 55.0%, respec

• br Conflict of interest statement br Acknowledgements

  2020-07-25

  

  Conflict of interest statement Acknowledgements Introduction Spending their last days on earth having already lost many cognitive functions remains a major fear of elderly people. Although during the last century their lifespans increased, the so-called “old-age diseases” became more and mo

• During the first year of life there

  2020-07-25

  

  During the first year of life, there was no interaction between cholesterol precursors and cholestanol, suggesting that cholesterol homeostasis was not yet developed. From the age of 1 year, cholesterol homeostasis could be considered intact. According to Fig. 1, cholesterol Dihydrodaidzein prevail

• br Conclusion To our knowledge this study is the

  2020-07-25

  

  Conclusion To our knowledge, this study is the first to give evidence that the ETA selective antagonist BQ-123 reverses the cisplatin-induced ARF mainly via restoring SOD activity, in addition to other antioxidant parameters, NO, TNF-α and caspase-3 levels. And that this protective effect require

• The highest concentrations from several tens to often hundre

  2020-07-25

  

  The highest concentrations (from several tens to often hundreds or thousands ng/L) are reported in animal farm flush water, and associated runoffs and lagoons in China and in the U.S. Lower concentrations are reported in WWTP influents and effluents. In WWTP influent waters DRO, LNG, NET and PRG hav

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