• br Introduction Glycoproteins represent a staggeringly small

  2021-09-14

  

  Introduction Glycoproteins represent a staggeringly small fraction of proteins analyzed by high-resolution techniques despite high concentrations at the cell surface and critical roles in many human diseases. Though one-half or more of all human proteins are predicted to contain a carbohydrate ch

• High energy adjusted free glutamate intake among adults with

  2021-09-14

  

  High energy-adjusted free glutamate intake among adults with high education level (above college) or high poverty income ratio (≥3.50) might be a consequence of the difference in intake of some foods such as vegetables and fruits, reflecting upon their socioeconomic status. Previous studies have sho

• By regulation of synaptic glutamate concentration glutamate

  2021-09-13

  

  By regulation of synaptic glutamate concentration, glutamate transporters play an important role in limiting glutamate signaling and controlling the activation of glutamate receptors (Rimmele and Rosenberg, 2016). Reduced glutamate transport is thought to underlie the pathogenesis of numerous neurol

• Prolonged sGC oxidative inhibition occurs

  2021-09-13

  

  Prolonged sGC oxidative inhibition occurs in many diseases [46,[86], [87], [88]]. Keeping sGC membrane-bound and functional under conditions of high oxidative stress requires a mechanism for restoring oxidized sGC (Fe3+) heme iron to its reduced (Fe2+) state. Without this redox regulation, the sGC e

• In the pathogenesis of insulin

  2021-09-13

  

  In the pathogenesis of insulin resistance, chronic activation of inflammatory pathways plays an important role, and the macrophage/adipocyte inter-communication provides a key mechanism underlying the common disease states of decreased insulin sensitivity [10]. This involves the migration of macroph

• br Discussion Our results indicate

  2021-09-13

  

  Discussion Our results indicate that marked changes in the relative distribution of AMPA receptors in microsomal and synaptic fractions occur during the postnatal period, and that these changes are correlated with changes in different populations of AMPA binding sites. At early postnatal ages (PN

• br Summary br Acknowledgement br GR

  2021-09-13

  

  Summary Acknowledgement GR: A Nuclear Receptor with Widespread Physiological Impact GR, or NR3C1 (see Glossary), is a transcription factor (TF) that regulates gene expression in nearly every cell of the body. A member of the nuclear receptor (NR) superfamily, its ligand-binding domain confe

• From a cell signaling perspective given the importance of

  2021-09-13

  

  From a cell signaling perspective, given the importance of agonist-directed signaling and biased agonism, one goal of this research update was to review the known contributions of G protein-dependent versus β-arrestin-dependent signals toward promotion of beneficial functions that FFA4 facilitates.

• One effective approach to fine

  2021-09-13

  

  One effective approach to fine-tuning the lipophilicity profile of FFA1 agonists is to ‘decorate’ the 3-phenylpropahoic dizocilpine mg scaffold with polar heterocyclic moieties. Alternatively, this scaffold could be replaced with heterocyclic isosteres (as in Takeda’s compounds 1,2 and 3 as well as

• BIIB021 receptor Channeling of SFA away from generation of

  2021-09-13

  

  Channeling of SFA away from generation of toxic lipid metabolites such as ceramide, towards inert TG accumulation in response to cosupplementation with increased levels of MUFAs has previously been shown in many cell types including the pancreatic β-cells [37]. Our studies indicate that similar mech

• The inhibitory activities of the compounds with

  2021-09-13

  

  The inhibitory activities of the compounds with the modification of the amino group against human liver FBPase are summarized in . Replacement of the amino group of with hydrophobic substituent such as a methyl group () led to a substantial loss of activity (IC=995nM). Similarly, replacement with h

• In human cancers it has

  2021-09-13

  

  In human cancers, it has been identified that FOXC2-AS1 functions as an oncogenic RNA. For instance, in osteosarcoma, FOXC2-AS1 regulates the expression of FOXC2 at the transcription and post-transcription levels to promote doxorubicin resistance by facilitating ABCB1 expression (C.L. Zhang et al.,

• Substitutions V L F V and Q H

  2021-09-11

  

  Substitutions V36L, F43V and Q80H were identified in the present study. RAS V36L is associated with resistance to boceprevir [18]. In 2015, Brazilian clinical practice guidelines on the management of hepatitis C no longer included combined therapies with boceprevir or telaprevir as a treatment optio

• br Conclusion The wild study reports seasonal variations

  2021-09-11

  

  Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and Protease Inhibitor Cocktail (100X in DMSO, EDTA plus) plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher ex

• BCCA occlusion followed by reperfusion injury significantly

  2021-09-11

  

  BCCA occlusion, followed by reperfusion injury, significantly increased the brain AT1 and AT2 receptor expression in mice. Reports have demonstrated elevation of AT1 receptor expression in the cerebral taselisib during ischemia [34,35]. The gene expression of brain AT2 receptor is increased in both

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