• br Therapeutic approaches exploiting Cx function Due to

  2022-01-12

  

  Therapeutic approaches exploiting Cx43 function Due to their potential role in cancer metastasis, attempts have been made to alter connexin function to inhibit cancer growth. Therapeutic approaches include Cx43 peptide mimetics, Cx43 inhibitors, chemical agents capable of enhancing Cx43 function,

• Michiel S van der Heijden had full access

  2022-01-12

  

  Michiel S. van der Heijden had full access to all Eribulin mesylate data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Wang, Sustic, de Oliveira, van den Heuvel, Bernards, van der Heijden. Wang, Sustic, de Oliveira, van de Ven. Wang

• In this study we intended to explore the efficacy of

  2022-01-12

  

  In this study, we intended to explore the efficacy of artesunate on liver fibrosis and further clarify its potential molecular mechanism. Artemisinin, a sesquiterpene lactone obtained from a Chinese plant Artemisia annua [27]. Artesunate, as a stable derivative of artemisinin, is an effective drug f

• In addition to indoles two additional structural variants

  2022-01-12

  

  In addition to indoles –, two additional structural variants were synthesized to explore the synthetic flexibility and structure–activity relationships of this system. The first of these was the homologation of the acetic Sulindac sulfide side chain to prepare compound (). The extension of the cha

• Since stroke and cerebrovascular diseases were considered se

  2022-01-12

  

  Since stroke and cerebrovascular diseases were considered serious AEs following vaccination, we performed manual chart review to confirm the diagnosis and symptom onset date for all stroke and cerebrovascular disease cases identified by ICD-9 codes. Chart review of 131 presumptive cases confirmed 82

• Under normal physiological conditions the body

  2022-01-12

  

  Under normal physiological conditions, the body has sufficient oxygen supply, so glucose can produce large amounts of ATP by aerobic oxidation and oxidative phosphorylation in cells. After SCI, hypoxia ischemia can occur in local tissue, leading to decreasing of intracellular oxygen partial pressure

• RS testing has been extensively validated in patients with

  2022-01-12

  

  RS testing has been extensively validated in patients with early stage, ER+, HER2− patients. TAILORx, a randomized controlled trial to evaluate the role of adjuvant chemotherapy by RS, found no recurrence or survival benefit to the addition of chemotherapy to endocrine therapy in patients with inter

• The present studies show that despite the high level of

  2022-01-12

  

  The present studies show that, despite the high level of GSTP1-1 achieved in transfected cells, GSTP1-1 expression has no effect on sensitivities to the cytotoxicities of the oxazaphosphorines 4-OH-CP, 4-OOH-CP, and maf in MCF7 Okadaic acid (Fig. 4). The failure of GSTP1-1 to augment resistance ind

• The treatment target which aims at diagnosing of HIV

  2022-01-12

  

  The “90-90-90 treatment target” which aims at diagnosing 90% of HIV-infected individuals, treating 90% of those diagnosed and achieve viral suppression for 90% of treated individuals, is a key strategy to achieve one of the sustainable development goals (SDG) of ending AIDS as a public health threat

• Glycogen synthase kinase GSK is currently considered

  2022-01-12

  

  Glycogen synthase kinase 3 (GSK3) is currently considered to be a multifunctional serine/threonine kinase involved in a wide spectrum of cellular processes such as glycogen metabolism, cell proliferation, neuronal function, oncogenesis or embryonic development (for recent reviews see: Rayasam et al.

• Because sleep and metabolism are

  2022-01-11

  

  Because sleep and metabolism are intimately linked, the authors next move to study whether Eaat2 also controls metabolic rate. First, we must ask how sleep and metabolism are connected at a functional level. The Primaquine Diphosphate allocation hypothesis of sleep posits that organisms temporally p

• In addition to GABA mediated mIPSCs

  2022-01-11

  

  In addition to GABA-mediated mIPSCs, glutamate-mediated miniature excitatory postsynaptic potentials (mEPSCs) regulate the excitability of the nervous system. GluRs can be divided into ionic and metabotropic GluRs. Ionotropic GluRs can be pharmacologically differentiated by specific binding of the a

• PP121 receptor Many studies support that Gli transcription f

  2022-01-11

  

  Many studies support that Gli transcription factors are not solely regulated by Hh/smo signaling but are also influenced by crosstalk with other pathways, such as RAS, PI3K/AKT, transforming growth factor-b/SMAD, PKC, or extracellular signal-regulated kinase pathways which are downstream and indepen

• br Acknowledgements br Introduction Ghrelin is a potent

  2022-01-11

  

  Acknowledgements Introduction Ghrelin is a potent orexigenic hormone and growth hormone secretagogue mainly derived from the stomach [1], [2], [3], [4], [5]. Other pleiotropic actions of the hormone include those that are glucoregulatory, food reward-enhancing, gastric motility-enhancing, and

• Irpex lacteus was well known as an edible and

  2022-01-11

  

  Irpex lacteus was well known as an edible and medicinal mushroom. It had been reported that I. lacteus could produce a thermostable α-galactosidase [17]. The reported α-galactosidase from I. lacteus, however, seemed to be unsuitable for the practical application due to its poor hydrolysis ability t

15508 records 496/1034 page Previous Next First page 上5页 496497498499500 下5页 Last page